• 
  Independiente R – Deportivo

  17 December

• 
  Atletico Tucuman – Central

  17 December

• 
  Talleres de Cordoba – Newell`s

  15 December

• 
  Velez – Huracan

  15 December

• 
  Atletico Platense – Gimnasia

  15 December

• 
  Defensa y Justicia – Union

  15 December

• 
  Bournemouth – West

  16 December

• 
  Southampton – Tottenham

  15 December

• 
  Chelsea – Brentford

  15 December

• 
  Manchester City – Manchester

  15 December

• 
  PSG – Lyon

  15 December

• 
  Brest – Nantes

  15 December

• 
  Rennes – Angers

  15 December

• 
  Le Havre – Strasbourg

  15 December

• 
  RB Leipzig – Eintracht

  15 December

• 
  Dortmund – Hoffenheim

  15 December

• 
  Lazio – Inter

  16 December

• 
  Milan – Genoa

  15 December

• 
  Como – Roma

  15 December

• 
  Amur – Admiral

  17 December

• 
  Monterrey – America

  16 December

• 
  NAC Breda – AZ

  15 December

• 
  Ajax – Almere City

  15 December

• 
  Rio Ave – Guimaraes

  16 December

• 
  Porto – Estrela

  16 December

• 
  Braga – Famalicao

  16 December

• 
  Estoril Praia – Casa Pia

  15 December

• 
  AVS – Benfica

  15 December

• 
  Arouca – Santa Clara

  15 December

• 
  Rapid Bucuresti – Gloria

  16 December

• 
  Farul – FCSB

  15 December

• 
  Barcelona – Leganes

  15 December

• 
  Villarreal – Real Betis

  15 December

• 
  Real Sociedad – Las

  15 December

• 
  Alaves – Athletic Bilbao

  15 December

• 
  Galatasaray – Trabzonspor

  16 December

• 
  Adana – Besiktas

  16 December

• 
  Fenerbahce – Basaksehir

  15 December

• 
  Dynamo Kyiv – Veres

  16 December

• 
  Polissya – Shakhtar

  15 December

• 
  Partizan – Buducnost

  15 December

• 
  Studentski Centar – Crvena

  15 December

• 
  Ilirija – Sibenik

  16 December

• 
  Qarabag – Sumqayit

  16 December

• 
  CSKA 1948 – Ludogorets

  16 December

• 
  Levski Krumovgrad – Arda

  16 December

• 
  Levski – Academic

  16 December

• 
  Beroe – Balkan

  15 December

• 
  Jiangsu Dragons – Guangdong

  16 December

• 
  Shanxi Loongs – Liaoning

  16 December