• 
  San Lorenzo – Tigre

  14 December

• 
  Banfield – Sarmiento

  14 December

• 
  Estudiantes LP – Argentinos

  13 December

• 
  Barracas Central – Lanus

  13 December

• 
  St Gallen – Guimaraes

  12 December

• 
  The – Panathinaikos

  12 December

• 
  Gent – Backa Topola

  12 December

• 
  Omonia – Rapid Vienna

  12 December

• 
  Shamrock Rovers – Borac

  12 December

• 
  Pafos – Celje

  12 December

• 
  Petrocub – Real Betis

  12 December

• 
  Fiorentina – LASK

  12 December

• 
  Noah – APOEL

  12 December

• 
  Olimpija – Cercle

  12 December

• 
  Legia Warsaw – Lugano

  12 December

• 
  Basaksehir – Heidenheim

  12 December

• 
  HJK – Molde

  12 December

• 
  Copenhagen – Heart

  12 December

• 
  Rangers – Tottenham

  12 December

• 
  Real Sociedad – Dynamo

  12 December

• 
  Lyon – Eintracht

  12 December

• 
  Slavia – Anderlecht

  12 December

• 
  Porto – Midtjylland

  12 December

• 
  Bodoe/Glimt – Besiktas

  12 December

• 
  Ajax – Lazio

  12 December

• 
  Elfsborg – Qarabag

  12 December

• 
  Maccabi Tel Aviv – RFS

  12 December

• 
  Viktoria Plzen – Manchester

  12 December

• 
  Roma – Braga

  12 December

• 
  Ludogorets – AZ

  12 December

• 
  Malmoe – Galatasaray

  12 December

• 
  PAOK – Ferencvaros

  12 December

• 
  Union – Nice

  12 December

• 
  Olympiacos – Twente

  12 December

• 
  Hoffenheim – FCSB

  12 December

• 
  Freiburg – Wolfsburg

  13 December

• 
  Empoli – Torino

  13 December

• 
  America – Monterrey

  13 December

• 
  Dinamo Bucharest – Politehnica

  13 December

• 
  Botosani – Hermannstadt

  13 December

• 
  Espanyol – Osasuna

  14 December

• 
  Real – Valencia

  13 December

• 
  Kasimpasa – Eyupspor

  13 December

• 
  Bodrumspor – Sivasspor

  13 December

• 
  Oleksandria – LNZ

  14 December

• 
  Vorskla – Livyi Bereh

  13 December

• 
  FMP – Split

  13 December

• 
  Zadar – Borac

  12 December

• 
  Perth Glory – Newcastle

  14 December

• 
  Western Sydney – Brisbane

  14 December