• 
  Arsenal – AS Monaco

  11 December

• 
  Juventus – Manchester

  11 December

• 
  Dortmund – Barcelona

  11 December

• 
  Benfica – Bologna

  11 December

• 
  Feyenoord – Sparta

  11 December

• 
  Milan – Crvena Zvezda

  11 December

• 
  Stuttgart – Young Boys

  11 December

• 
  Atletico Madrid – Slovan

  11 December

• 
  Lille – Sturm Graz

  11 December

• 
  St Gallen – Guimaraes

  12 December

• 
  The – Panathinaikos

  12 December

• 
  Gent – Backa Topola

  12 December

• 
  Omonia – Rapid Vienna

  12 December

• 
  Shamrock Rovers – Borac

  12 December

• 
  Pafos – Celje

  12 December

• 
  Petrocub – Real Betis

  12 December

• 
  Fiorentina – LASK

  12 December

• 
  Noah – APOEL

  12 December

• 
  Olimpija – Cercle

  12 December

• 
  Legia Warsaw – Lugano

  12 December

• 
  Basaksehir – Heidenheim

  12 December

• 
  HJK – Molde

  12 December

• 
  Copenhagen – Heart

  12 December

• 
  Astana – Chelsea

  12 December

• 
  Vikingur – Djurgarden

  12 December

• 
  Rangers – Tottenham

  12 December

• 
  Real Sociedad – Dynamo

  12 December

• 
  Lyon – Eintracht

  12 December

• 
  Slavia – Anderlecht

  12 December

• 
  Porto – Midtjylland

  12 December

• 
  Bodoe/Glimt – Besiktas

  12 December

• 
  Ajax – Lazio

  12 December

• 
  Elfsborg – Qarabag

  12 December

• 
  Maccabi Tel Aviv – RFS

  12 December

• 
  Viktoria Plzen – Manchester

  12 December

• 
  Roma – Braga

  12 December

• 
  Ludogorets – AZ

  12 December

• 
  Malmoe – Galatasaray

  12 December

• 
  PAOK – Ferencvaros

  12 December

• 
  Union – Nice

  12 December

• 
  Olympiacos – Twente

  12 December

• 
  Hoffenheim – FCSB

  12 December

• 
  Fenerbahce – Athletic

  11 December

• 
  Zadar – Borac

  12 December

• 
  Velez Sarsfield – Central

  12 December

• 
  Brisbane Bullets – SE

  12 December

• 
  NZ Breakers – Tasmania

  12 December

• 
  Kolossos – Saint-Quentin

  11 December

• 
  Falco Szombathely – Slask

  11 December

• 
  Xinjiang Flying Tigers – Liaoning

  11 December