• 
  Huracan – Atletico

  10 December

• 
  Independiente – Atletico

  10 December

• 
  Arsenal – AS Monaco

  11 December

• 
  Juventus – Manchester

  11 December

• 
  Dortmund – Barcelona

  11 December

• 
  Benfica – Bologna

  11 December

• 
  Feyenoord – Sparta

  11 December

• 
  Milan – Crvena Zvezda

  11 December

• 
  Stuttgart – Young Boys

  11 December

• 
  Atletico Madrid – Slovan

  11 December

• 
  Lille – Sturm Graz

  11 December

• 
  Atalanta – Real

  10 December

• 
  RB Leipzig – Aston Villa

  10 December

• 
  Shakhtar Donetsk – Bayern

  10 December

• 
  Brest – PSV

  10 December

• 
  Leverkusen – Inter

  10 December

• 
  RB Salzburg – PSG

  10 December

• 
  Brugge – Sporting

  10 December

• 
  Girona – Liverpool

  10 December

• 
  Dinamo Zagreb – Celtic

  10 December

• 
  Fenerbahce – Athletic

  11 December

• 
  Obras – Union Santa Fe

  11 December

• 
  Kolossos – Saint-Quentin

  11 December

• 
  Falco Szombathely – Slask

  11 December

• 
  Benfica – Manresa

  10 December

• 
  Tenerife – Karsiyaka

  10 December

• 
  Bonn – VEF Riga

  10 December

• 
  Chemnitz – Derthona

  10 December

• 
  Ironi Ramat Gan – AEK

  10 December

• 
  Shanghai Sharks – Tianjin

  10 December

• 
  Zhejiang Lions – Shenzhen

  10 December

• 
  Sada Cruzeiro – Ciudad

  11 December

• 
  Sirjan – Lube

  10 December

• 
  Union – Llaneros

  11 December

• 
  Leeds – Middlesbrough

  10 December

• 
  Plymouth Argyle – Swansea

  10 December

• 
  Sunderland – Bristol

  10 December

• 
  Burnley – Derby County

  10 December

• 
  Luton Town – Stoke City

  10 December

• 
  Portsmouth – Norwich

  10 December

• 
  Sheffield – Blackburn

  10 December

• 
  Gran Canaria – Buducnost

  11 December

• 
  Joventut – Ulm

  11 December

• 
  Venezia – Cedevita

  11 December

• 
  Hapoel – Lietkabelis

  11 December

• 
  Besiktas – Bahcesehir

  11 December

• 
  Cluj-Napoca – JL Bourg

  11 December

• 
  Turk Telekom – Aris

  11 December

• 
  Wolves – Hapoel T-A

  11 December

• 
  Hamburg – Valencia

  10 December