• 
  Huracan – Atletico

  10 December

• 
  Independiente – Atletico

  10 December

• 
  Argentinos Juniors – San

  9 December

• 
  Belgrano – Estudiantes

  9 December

• 
  Tigre – Independiente R

  9 December

• 
  Atalanta – Real

  10 December

• 
  RB Leipzig – Aston Villa

  10 December

• 
  Shakhtar Donetsk – Bayern

  10 December

• 
  Brest – PSV

  10 December

• 
  Leverkusen – Inter

  10 December

• 
  RB Salzburg – PSG

  10 December

• 
  Brugge – Sporting

  10 December

• 
  Girona – Liverpool

  10 December

• 
  Dinamo Zagreb – Celtic

  10 December

• 
  West – Wolverhampton

  9 December

• 
  Monza – Udinese

  9 December

• 
  Estrela – Arouca

  9 December

• 
  U Cluj – CFR Cluj

  9 December

• 
  Hermannstadt – Otelul

  9 December

• 
  Getafe – Espanyol

  9 December

• 
  Gaziantep – Rizespor

  9 December

• 
  Polissya – Rukh

  9 December

• 
  Crvena Zvezda – Cibona

  9 December

• 
  Mega Bemax – Borac

  9 December

• 
  Split – Krka

  9 December

• 
  Obras – Union Santa Fe

  11 December

• 
  Turan Tovuz – Shamakhi

  9 December

• 
  Spartak Varna – Slavia

  9 December

• 
  Beroe – Cherno More

  9 December

• 
  Benfica – Manresa

  10 December

• 
  Tenerife – Karsiyaka

  10 December

• 
  Bonn – VEF Riga

  10 December

• 
  Chemnitz – Derthona

  10 December

• 
  Ironi Ramat Gan – AEK

  10 December

• 
  Shanghai Sharks – Tianjin

  10 December

• 
  Zhejiang Lions – Shenzhen

  10 December

• 
  Sirjan – Lube

  10 December

• 
  Union – Llaneros

  11 December

• 
  Leeds – Middlesbrough

  10 December

• 
  Plymouth Argyle – Swansea

  10 December

• 
  Sunderland – Bristol

  10 December

• 
  Burnley – Derby County

  10 December

• 
  Luton Town – Stoke City

  10 December

• 
  Portsmouth – Norwich

  10 December

• 
  Sheffield – Blackburn

  10 December

• 
  Hamburg – Valencia

  10 December

• 
  Trefl Sopot – Trento

  10 December

• 
  PAOK – Promitheas

  9 December

• 
  Oklahoma – Dallas

  11 December

• 
  Milwaukee – Orlando

  11 December